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Free T4

Does this test have other names?

Free thyroxine test

What is this test?

This test measures the level of free T4, or free thyroxine, in your blood. A free T4 test is used to find out how well your thyroid gland is working.

T4 is one of two hormones produced by the thyroid, a butterfly-shaped gland in your neck. There are two forms of T4. Some T4 in your blood is bound to proteins, and some T4 circulates freely, or unbound from proteins. Testing for unbound T4 is more accurate than testing for bound T4. The free T4 test measures unbound T4.

The other thyroid hormone is triiodothyronine, or T3. T4 is changed to T3 in order to become active and effective. There are also two forms of T3, just T3 and free T3. 

These hormones help regulate your body's metabolism. They go into action when prompted by thyroid stimulating hormone (TSH), which is released by the pituitary gland in your brain.

Why do I need this test?

You may need this test if your healthcare provider wants to find out whether you have a thyroid-related condition such as hyperthyroidism, which means an overactive thyroid, or hypothyroidism, which means an underactive thyroid. If you do have a thyroid problem, you may have the test to monitor changes or treatment. 

Each condition has many different symptoms. If you have hyperthyroidism, you may often feel anxious and irritable, have trouble sleeping, and have an irregular or rapid heart rhythm. You may also feel quite tired and notice that you're losing weight even though your appetite has increased.

If you have hypothyroidism, you may notice weight gain, even if you aren't overeating. You may also be more sensitive to cold, have low energy, and have dry skin and hair. 

What other tests might I have along with this test?

You may have blood tests to measure T3 and TSH. These hormones also play key roles in thyroid health. You may also have blood tests to measure the levels of certain antithyroid antibodies in your blood to get a more accurate diagnosis. And, you may have imaging tests of your thyroid gland. 

What do my test results mean?

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The normal range for free T4 in adults is 0.8 to 2.8 nanograms per deciliter (ng/dL). A level of free T4 that is higher than normal could mean you have an overactive thyroid. Conditions associated with hyperthyroidism include Graves disease, an autoimmune disorder.

Abnormally low free T4 levels may signal hypothyroidism. This means your thyroid is not making enough hormones. An underlying condition, such as Hashimoto disease, another autoimmune disorder, could be the cause of an underactive thyroid. 

How is this test done?

The test needs a blood sample, which is drawn through a needle from a vein in your arm.

Does this test pose any risks?

Having a blood test with a needle carries some risks. These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore. 

What might affect my test results?

Certain medicines, such as phenobarbital, can affect your free T4 levels. Severe chronic illnesses, such as chronic renal failure and cirrhosis of the liver, can also affect the test.

How do I get ready for this test?

You don't need to prepare for this test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use. 

Online Medical Reviewer: Greco, Frank, MD
Online Medical Reviewer: Holloway, Beth Greenblatt, RN, MEd
Date Last Reviewed: 9/1/2017
© 2000-2019 The StayWell Company, LLC. 800 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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